The two sides have not met in the competition since the 2011 final at Wembley and winner will face either Liverpool or Porto
As predicted, the quarter-final draw of the Champions League produced a number of exciting ties as the Premier League sides discovered their fate.
Liverpool were handed the all-English tie when they were drawn against Manchester City, Liverpool will face Porto, while Manchester United have been pitted against the might of Lionel Messi and Barcelona.
Barcelona and Man United last met in this competition in 2011
It means United boss Ole Gunnar Solskjaer will return to the Nou Camp, 20 years on from his famous winner against Bayern Munich, when Sir Alex Ferguson’s side famously came from a goal down to complete their treble triumph in 1999.
United have faced Barcelona eight times in the competition since 1994 and have only won once, a 1-0 win in 2008 courtesy of Paul Scholes.
Scholes netted the winner in 2008 against Barcelona
The last time they met was in the final at Wembley eight years ago, when Barcelona recorded a 3-1 victory for their fourth success in the tournament.
Old Trafford will host the first-leg on the 9/10 April, while the return fixture will be held on either 16/17 April and should they advance they will face the winner of Liverpool or Porto.
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Here are how fans reacted to the draw on social media below